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These include mRNA species, which have distinct advantages including lack of unwanted immune responses, brain-specific targeting, and improved safety profiles[191,192], and CRISPR/Cas9 technology as shown by nanoparticle-mediated brain delivery of an Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) gene editing construct that decreased glioblastoma invasion capacity[193]

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doi: 10.1016/j.pbiomolbio.2021.05.010